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Bioorg Med Chem Lett. 2006 May 1;16(9):2528-31. Epub 2006 Feb 7.

Substituted coumarins as potent 5-lipoxygenase inhibitors.

Author information

1
Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Hwy, Kirkland, Que., Canada H9H 3L1. erich_grimm@merck.com

Abstract

Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure-activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme.

PMID:
16464579
DOI:
10.1016/j.bmcl.2006.01.085
[Indexed for MEDLINE]

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