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Ned Tijdschr Geneeskd. 2006 Jan 21;150(3):140-2.

[From the Cochrane Library: Improvement of photodamaged skin with retinoid creams and not with other local treatments].

[Article in Dutch]

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Academisch Medisch Centrum/Universiteit van Amsterdam, Dutch Cochrane Centre, Amsterdam.


A Cochrane systematic review of 30 randomised clinical trials assessed the effects of current treatments for adults with mild-to-severe changes in facial and forearm skin that occurred as a result of prolonged exposure to the sun ('photodamage'). Topical tretinoin > or = 0.02% improved the appearance of mild-to-severe photodamage. Tazarotene 0.01-0.1% and isotretinoin 0.1% provided benefit to patients with moderate photodamage. The treatment duration was 4-11 months. Adverse effects were pain and redness. Both the efficacy and adverse effects were dose-dependent. Other treatments, such as polysaccharides, hydroxy acids, surgical procedures and laser, cannot be recommended.

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