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Nat Med. 2006 Feb;12(2):178-80. Epub 2006 Feb 5.

Natural regulatory T cells control the development of atherosclerosis in mice.

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Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 689, Centre de Recherche Cardiovasculaire Lariboisière, 41, Bd de la Chapelle, 75010 Paris, France.


Atherosclerosis is an immunoinflammatory disease elicited by accumulation of lipids in the artery wall and leads to myocardial infarction and stroke. Here, we show that naturally arising CD4(+)CD25(+) regulatory T cells, which actively maintain immunological tolerance to self and nonself antigens, are powerful inhibitors of atherosclerosis in several mouse models. These results provide new insights into the immunopathogenesis of atherosclerosis and could lead to new therapeutic approaches that involve immune modulation using regulatory T cells.

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