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J Clin Virol. 2005 Dec;34 Suppl 1:S1-3.

Worldwide epidemiology of HBV infection, disease burden, and vaccine prevention.

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World Health Organization, Department of Communicable Diseases Surveillance and Response, Geneva, Switzerland.


Worldwide, hepatitis B virus (HBV) is the most common among those hepatitis viruses that cause chronic infections of the liver in humans, and it represents a global public health problem. Chronic hepatitis caused by HBV is the major cause of hepatocellular carcinoma (HCC) worldwide, and remains therefore a major public health problem globally. This fact is related to both the continuing occurrence of frequent new infections and to the presence of a large reservoir of persons chronically infected, which may develop severe and fatal complications of chronic liver disease. Hepatitis B and all of the complications resulting from it, as well hepatitis D (HDV) and its complications, are globally preventable by hepatitis B vaccination, and therefore elimination of HBV transmission and of new acute and chronic infections is a feasible goal.

[Indexed for MEDLINE]

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