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Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. Epub 2006 Feb 3.

Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis.

Author information

1
Hoffmann-La Roche Inc., 340 Kingsland Str., Nutley, NJ 07110-1199, USA. lee.mcdermott@roche.com

Abstract

RO4396686 is a small molecule KDR, FGFR, and PDGFR inhibitor with good pharmacokinetic properties in rodents. In a mouse corneal neovascularization assay, this compound inhibited VEGF-induced angiogenesis. Tested in a H460a xenograft tumor model this agent effected significant tumor growth inhibition at doses as low as 50mg/kg.

PMID:
16460940
DOI:
10.1016/j.bmcl.2005.12.092
[Indexed for MEDLINE]

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