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J Physiol Paris. 2006 Mar-May;99(2-3):146-53. Epub 2006 Feb 7.

The striatin family: a new signaling platform in dendritic spines.

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INSERM-UMR 641, Institut Jean Roche, Université de la Méditerranée, Faculté de Médecine Secteur-Nord, Boulevard P. Dramard, 13916 Marseille cedex 20, France.


Proteins of the striatin family have been identified in all multicellular animals. They are multidomain molecules containing several protein-interacting motifs. In mammals, these proteins are principally expressed in neurons with a somato-dendritic localization and high concentration in dendritic spines. Recent reports suggest that the proteins of the striatin family are molecular scaffolds that act as links between signal transduction and vesicular trafficking.

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