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J Biol Chem. 2006 May 26;281(21):14529-32. Epub 2006 Feb 3.

Regulation of ornithine decarboxylase.

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1
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. aep1@psu.edu

Abstract

Ornithine decarboxylase (ODC) initiates the polyamine biosynthetic pathway. The amount of ODC is altered in response to many growth factors, oncogenes, and tumor promoters and to changes in polyamine levels. Susceptibility to tumor development is increased in transgenic mice expressing high levels of ODC and is decreased in mice with reduced ODC due to loss of one ODC allele or elevated expression of antizyme, a protein that stimulates ODC degradation. This review describes key factors that contribute to the regulation of ODC levels, which can occur at the levels of transcription, translation, and protein turnover.

PMID:
16459331
DOI:
10.1074/jbc.R500031200
[Indexed for MEDLINE]
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