Format

Send to

Choose Destination
Trends Immunol. 2006 Mar;27(3):109-11. Epub 2006 Feb 3.

The dichotomous role of IL-2: tolerance versus immunity.

Author information

1
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.

Abstract

Interleukin-2 (IL-2) is a well-known T-cell growth factor, which is traditionally implicated in the agonistic stimulation of immune responses. Recent work, however, has uncovered an unexpected function of this cytokine. In particular, IL-2 appears crucial to maintaining peripheral tolerance by supporting the survival and function of CD25+ CD4+ regulatory T cells. A recent study examining the role of IL-2 in the peripheral generation of regulatory T cells from apparently naïve T cells has gone some way to reconciling the seemingly opposing functions of this cytokine.

PMID:
16459146
DOI:
10.1016/j.it.2006.01.005
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center