Format

Send to

Choose Destination
Phytochemistry. 2006 Mar;67(6):618-21. Epub 2006 Feb 3.

An angiotensin-I converting enzyme inhibitor from buckwheat (Fagopyrum esculentum Moench) flour.

Author information

1
Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado, Saitama 350-0288, Japan. aoyagi@eiyo.ac.jp

Abstract

A compound that inhibited angiotensin-I converting enzyme (ACE) activity was isolated from buckwheat powder. This compound is thought to be the hydroxy derivative of nicotianamine and its chemical structure is 2''-hydroxynicotianamine. This compound showed a very high inhibitory activity toward ACE, and the IC(50) was 0.08 microM. Only this hydroxy analog was found in buckwheat powder, at about 30 mg/100g, and no nicotianamine was detected. However, nicotianamine was detected in the buckwheat plant body. 2''-hydroxynicotianamine was also found in other polygonaceous plants.

PMID:
16458941
DOI:
10.1016/j.phytochem.2005.12.022
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center