Format

Send to

Choose Destination
See comment in PubMed Commons below
J Urol. 2006 Mar;175(3 Pt 2):S5-10.

Overactive bladder: a better understanding of pathophysiology, diagnosis and management.

Author information

  • 1University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA. alan.wein@uphs.upenn.edu

Abstract

PURPOSE:

We reviewed current information regarding the updated definitions, prevalence, etiologies, disease burden, and management of OAB from a number of perspectives, including professional impact and patient quality of life.

MATERIALS AND METHODS:

Published literature and current treatment concepts were reviewed regarding the understanding and management of OAB.

RESULTS:

OAB is a symptom syndrome including urinary urgency with or without urinary incontinence, usually with frequency and nocturia. Approximately 17% of the adult population experience OAB. There are evolving theories regarding its pathophysiology and the mechanism of action of the most commonly prescribed pharmacological therapy (antimuscarinic agents). Treatment primarily revolves around improving quality of life.

CONCLUSIONS:

Behavioral therapy combined with pharmacological therapy often will bring about acceptable outcomes for patients with OAB. Modalities such as botulinum toxin injections, neuromodulation, and various surgical interventions also are showing encouraging results in more refractory patients.

PMID:
16458739
DOI:
10.1016/S0022-5347(05)00313-7
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center