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Int J Radiat Oncol Biol Phys. 2006 Apr 1;64(5):1331-40. Epub 2006 Feb 3.

Role of intracanalicular volumetric and dosimetric parameters on hearing preservation after vestibular schwannoma radiosurgery.

Author information

1
Gamma Knife Center, Erasme Hospital, Université Libre de Brixelles, Brussels, Belgium. nmassage@ulb.ac.be

Abstract

PURPOSE:

To analyze the relationship between hearing preservation after gamma knife radiosurgery (GKR) for vestibular schwannoma (VS) and some volumetric and dosimetric parameters of the intracanalicular components of VS.

METHODS AND MATERIALS:

This study included 82 patients with a VS treated by GKR; all patients had no NF2 disease, a Gardner-Robertson hearing class 1-4 before treatment, a marginal dose of 12 Gy, and a radiologic and audiologic follow-up > or =1 year post-GKR. The volume of both the entire tumor and the intracanalicular part of the tumor and the mean and integrated dose of these two volumes were correlated to the auditory outcomes of patients.

RESULTS:

At last hearing follow-up, 52 patients had no hearing worsening, and 30 patients had an increase of > or =1 class on Gardner-Robertson classification. We found that hearing preservation after GKR is significantly correlated with the intracanalicular tumor volume, as well as with the integrated dose delivered to the intracanalicular tumor volume.

CONCLUSIONS:

Some volumetric and dosimetric parameters of the intracanalicular part of the tumor influence hearing preservation after GKR of VS. Consequently, we advise the direct treatment of patients with preserved functional hearing and a VS including a small intracanalicular volume.

PMID:
16458446
DOI:
10.1016/j.ijrobp.2005.10.030
[Indexed for MEDLINE]

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