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Dig Liver Dis. 2006 Mar;38(3):183-7. Epub 2006 Feb 7.

Anti-ganglioside antibodies in coeliac disease with neurological disorders.

Author information

1
Department of Internal Medicine, Cardioangiology and Hepatology, University of Bologna, Building 11, St. Orsola-Malpighi Hospital, Via Massarenti, 9, 40138 Bologna, Italy. uvolta@aosp.bo.it

Abstract

BACKGROUND:

Anti-ganglioside antibodies have been described in sera of coeliac patients with peripheral neuropathy and cerebellar ataxia.

AIMS:

To investigate the correlation between anti-ganglioside antibodies and neurological involvement in coeliac disease before and after gluten-free diet.

PATIENTS AND METHODS:

Twenty-two untreated coeliac patients with neurological dysfunction and 30 untreated coeliacs without neurological dysfunction, 20 patients with neurological disorders, 50 autoimmune disease and 20 blood donors were tested for anti-GM1, anti-GD1b and anti-GQ1b IgG and IgM antibodies by enzyme-linked immunosorbent assay.

RESULTS:

IgG antibodies to at least one of the three antigens tested were positive in 64% of coeliac patients with neurological symptoms compared to 30% of coeliacs without neurological dysfunction (P=0.02), 50% of patients with neurological disorders (P=ns), 20% with autoimmune diseases (P=0.003) and none of blood donors (P=0.0001). A strict gluten-free diet determined anti-ganglioside antibody disappearance in about half of coeliacs.

CONCLUSIONS:

A significant correlation between anti-ganglioside antibodies and neurological disorders in patients with an underlying coeliac disease has been found. Anti-ganglioside antibodies may represent a new immunological marker to identify neurological impairment in patients with coeliac disease.

PMID:
16458087
DOI:
10.1016/j.dld.2005.11.013
[Indexed for MEDLINE]
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