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Bioorg Med Chem. 2006 Jun 1;14(11):3654-61. Epub 2006 Feb 2.

Norbornyllactone-substituted xanthines as adenosine A(1) receptor antagonists.

Author information

1
Department of Medicinal Chemistry, Biogen Idec, Inc., 14 Cambridge Center, Cambridge, MA 02142, USA. william.kiesman@biogenidec.com

Abstract

During the search for second-generation adenosine A(1) receptor antagonist alternatives to the clinical candidate 8-(3-oxa-tricyclo[3.2.1.0(2,4)]oct-6-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione (BG9719), we developed a series of novel xanthines substituted with norbornyl-lactones that possessed high binding affinities for adenosine A(1) receptors and in vivo activity.

PMID:
16458010
DOI:
10.1016/j.bmc.2006.01.021
[Indexed for MEDLINE]

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