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Exp Mol Pathol. 2006 Aug;81(1):23-30. Epub 2006 Feb 2.

Different susceptibilities of PECAM-deficient mouse strains to spontaneous idiopathic pneumonitis.

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Department of Microbiology, Immunology and Pathology Colorado State University 1682 Campus Delivery Fort Collins, CO 80523-1682, USA.


Platelet Endothelial Cell Adhesion Molecule (PECAM) is an adhesion and signaling molecule used for leukocyte extravasation. We have generated two strains of PECAM-deficient mouse, one in the original C57BL/6 and a second by backcrossing nice generations into the FVB/n strain. The FVB/n strain has reduced responses in models of acute inflammation. We show here that this strain is also susceptible to a chronic pneumonia which leads to pulmonary fibrosis. In contrast, PECAM-deficient C57BL/6 mice do not develop this lung disease and have normal responses in acute models of inflammation. This demonstrates that PECAM-dependent and -independent mechanisms are found in both acute and chronic inflammation. Further, the PECAM-deficient FVB/n strain has many pathologic similarities to the human disease Idiopathic Pulmonary Fibrosis, suggesting that similar molecular mechanisms may play a role in human disease.

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