Structural-functional model of the mitotic chromosome

Biochemistry (Mosc). 2006 Jan;71(1):1-9. doi: 10.1134/s0006297906010019.

Abstract

In the present review the structural role of noncoding DNA, mechanisms of differential staining of mitotic chromosomes, and structural organization of different levels of DNA compactization are discussed. A structural-functional model of the mitotic chromosome is proposed based on the principle of discreteness of structural levels of DNA compactization.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Chromatin / chemistry
  • Chromatin / ultrastructure
  • Chromosomal Proteins, Non-Histone / chemistry
  • Chromosomal Proteins, Non-Histone / metabolism
  • Chromosomes / chemistry*
  • Chromosomes / metabolism*
  • Chromosomes / ultrastructure
  • Chromosomes, Human / chemistry*
  • Chromosomes, Human / metabolism*
  • Chromosomes, Human / ultrastructure
  • DNA / chemistry
  • Euchromatin / chemistry
  • Euchromatin / metabolism
  • Heterochromatin / chemistry
  • Heterochromatin / metabolism
  • Histones / chemistry
  • Histones / metabolism
  • Humans
  • Interphase
  • Mitosis*

Substances

  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • Euchromatin
  • Heterochromatin
  • Histones
  • DNA
  • Calcium