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J Membr Biol. 2005 Aug;206(3):173-85.

Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux.

Author information

1
Department of Medicine and Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.

Abstract

P-glycoprotein (P-gp) is an ATP-dependent drug pump that can transport a broad range of hydrophobic compounds out of the cell. The protein is clinically important because of its contribution to the phenomenon of multidrug resistance during AIDS/HIV and cancer chemotherapy. P-gp is a member of the ATP-binding cassette (ABC) family of proteins. It is a single polypeptide that contains two repeats joined by a linker region. Each repeat has a transmembrane domain consisting of six transmembrane segments followed by a hydrophilic domain containing the nucleotide-binding domain. In this mini-review, we discuss recent progress in determining the structure and mechanism of human P-glycoprotein.

PMID:
16456713
DOI:
10.1007/s00232-005-0792-1
[Indexed for MEDLINE]

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