Send to

Choose Destination
See comment in PubMed Commons below
Eur J Appl Physiol. 2006 Apr;96(6):627-35. Epub 2006 Feb 3.

Training-induced changes in membrane transport proteins of human skeletal muscle.

Author information

Copenhagen Muscle Research Centre, Institute of Molecular Biology and Physiology, University of Copenhagen, August Krogh Building, Universitetsparken 13, 2100 Copenhagen, Denmark.


Training improves human physical performance by inducing structural and cardiovascular changes, metabolic changes, and changes in the density of membrane transport proteins. This review focuses on the training-induced changes in proteins involved in sarcolemmal membrane transport. It is concluded that the same type of training affects many transport proteins, suggesting that all transport proteins increase with training, and that both sprint and endurance training in humans increase the density of most membrane transport proteins. There seems to be an upper limit for these changes: intense training for 6-8 weeks substantially increases the density of membrane proteins, whereas years of training (as performed by athletes) have no further effect. Studies suggest that training-induced changes at the protein level are important functionally. The underlying factors responsible for these changes in transport proteins might include changes in substrate concentration, but the existence of "exercise factors" mediating these responses is more likely. Exercise factors might include Ca(2+), mitogen-activated protein kinases, adenosine monophosphate kinases, other kinases, or interleukin-6. Although the magnitudes of training-induced changes have been investigated at the protein level, the underlying signal mechanisms have not been fully described.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center