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Curr Pharm Des. 2006;12(1):17-22.

Is there a role for cytokine based therapies in fibromyalgia.

Author information

1
Cedars-Sinai/David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. dwallace@ucla.edu

Abstract

Cytokines are glycoproteins that serve as chemical messengers between cells. They assist in the regulation of cell growth and repair and also have immune modulating properties. Cytokines play a role in diverse clinical processes and phenomena such as fatigue, fever, sleep, pain, stress and aching. A review of the fibromyalgia literature and related studies suggest that IL-1, IL-6 and IL-8 are dysregulated in the syndrome. Therapies directed against these cytokines may be of potential importance in the management of fibromyalgia.

PMID:
16454720
[Indexed for MEDLINE]

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