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Ann Neurol. 2006 Mar;59(3):566-9.

Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis.

Author information

1
Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. weinb@mayo.edu

Abstract

OBJECTIVE:

We investigated whether neuromyelitis optica (NMO) IgG seropositivity at the initial presentation of longitudinally extensive transverse myelitis (LETM) predicts relapse of myelitis or development of optic neuritis.

METHODS:

Prospective study of patients with initial LETM who were tested for the presence of NMO-IgG.

RESULTS:

Eleven of 29 patients (37.9%) were seropositive after a first attack of LETM spanning three or more vertebral segments on magnetic resonance imaging. Of 23 patients followed up for 1 year, none of 14 who were seronegative experienced a relapse or developed optic neuritis. Of 9 seropositive patients, 5 developed a second event: 4 of 9 (44%) developed recurrent transverse myelitis and 1 of 9 (11%) developed optic neuritis (p = 0.004).

INTERPRETATION:

LETM represents an inaugural or limited form of NMO in a high proportion of patients. The 40% of patients who are seropositive for NMO-IgG are at high risk for relapse.

PMID:
16453327
DOI:
10.1002/ana.20770
[Indexed for MEDLINE]

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