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Learn Mem. 2006 Jan-Feb;13(1):4-7.

Reduced extinction of hippocampal-dependent memories in CPEB knockout mice.

Author information

1
Department of Biology, Wellesley College, Wellesley, Massachusetts 02481, USA.

Abstract

CPEB is a sequence-specific RNA binding protein that regulates translation at synapses. In neurons of CPEB knockout mice, synaptic efficacy is reduced. Here, we have performed a battery of behavioral tests and find that relative to wild-type animals, CPEB knockout mice, although similar on many baseline behaviors, have reduced extinction of memories on two hippocampal-dependent tasks. A corresponding microarray analysis reveals that about 0.14% of hippocampal genes have an altered expression in the CPEB knockout mouse. These data suggest that CPEB-dependent local protein synthesis may be an important cellular mechanism underlying extinction of hippocampal-dependent memories.

PMID:
16452649
DOI:
10.1101/lm.73706
[Indexed for MEDLINE]

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