Format

Send to

Choose Destination
BMC Genet. 2005 Dec 30;6 Suppl 1:S69.

Robust testing of haplotype/disease association.

Author information

1
Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA. andrew.s.allen@duke.edu

Abstract

Haplotypes, the combination of closely linked alleles that fall on the same chromosome, show great promise for studying the genetic components of complex diseases. However, when only multilocus genotype data are available, statistical approaches need to be employed to resolve haplotype phase ambiguity. Recently, we have proposed an approach to testing and estimating haplotype/disease association that is invariant to any existing genetic structure in the population. Here we evaluate this approach by applying it to the Genetic Analysis Workshop 14 simulated data.

PMID:
16451682
PMCID:
PMC1866713
DOI:
10.1186/1471-2156-6-S1-S69
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center