A new neuroprotective compound of Ligustrum japonicum leaves

Planta Med. 2006 Jan;72(1):62-4. doi: 10.1055/s-2005-873140.

Abstract

A new secoiridoid glycoside characterized as (8 Z)-nuezhenide A along with five known glycosides, (8 E)-nuezhenide, (8 Z)-nuezhenide, oleonuezhenide, osmanthuside B and osmanthuside D, were isolated from the n-BuOH fraction of Ligustrum japonicum leaves. All six compounds significantly protected human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Humans
  • Ligustrum / chemistry*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / isolation & purification*
  • Oxidopamine
  • Plant Leaves / chemistry*

Substances

  • Neuroprotective Agents
  • Oxidopamine