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Intensive Care Med. 2006 Feb;32(2):237-243. doi: 10.1007/s00134-005-0017-1. Epub 2006 Feb 1.

Soluble triggering receptor expressed on myeloid cells 1 as an anti-inflammatory mediator in sepsis.

Author information

1
Fourth Department of Internal Medicine, University of Athens Medical School, University General Hospital Attikon, 1 Rimini Str., 12464, Athens, Greece. giamarel@ath.forthnet.gr.
2
First Department of Critical Care, Evangelismos Hospital, 17 Ipsilantou Str., 11526, Athens, Greece.
3
Fourth Department of Internal Medicine, University of Athens Medical School, University General Hospital Attikon, 1 Rimini Str., 12464, Athens, Greece.
4
Second Department of Critical Care, University of Athens Medical School, University General Hospital Attikon, 1 Rimini Str., 12464, Athens, Greece.

Abstract

OBJECTIVE:

To define the significance of soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) in the septic cascade by comparing its kinetics to those of other proinflammatory mediators and of interleukin (IL) 10.

DESIGN:

Prospective study in a tertiary unit.

PATIENTS:

Blood was sampled from 90 patients with septic syndrome due to ventilator-associated pneumonia for 7 days after the appearance of symptoms. Concentrations of tumor necrosis factor (TNF) alpha, IL-6, IL-8, IL-10, and sTREM-1 were determined by enzyme-linked immunosorbent assay.

RESULTS:

Serum levels of TNFalpha, IL-6, IL-10, and sTREM-1 were higher in nonsurvivors than in survivors; similar differences were not found for IL-8. Positive correlations were found between the ratios IL-10/TNFalpha and sTREM-1/TNFalpha, between IL-10/IL-6 and sTREM-1/IL-6, and between IL-10/IL-8 and sTREM-1/IL-8. Median values of IL-10/TNFalpha upon presentation of sepsis, severe sepsis, and septic shock were 3.21, 2.16, and 2.86, respectively (NS). Respective values for sTREM-1/TNFalpha were 21.28, 7.33, and 27.78 (p=0.047 between sepsis and severe sepsis, p=0.003 between severe sepsis and septic shock).

CONCLUSIONS:

sTREM-1 follows the kinetics of IL-10 and should therefore be considered an anti-inflammatory mediator in sepsis. Decreased ratios of sTREM-1/TNFalpha might determine transition from sepsis to severe sepsis and from severe sepsis to septic shock.

PMID:
16450102
DOI:
10.1007/s00134-005-0017-1
[Indexed for MEDLINE]

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