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Br J Cancer. 2006 Feb 27;94(4):455-9.

Mutation of the PIK3CA oncogene in human cancers.

Author information

1
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Department of Oncology, Baltimore, MD 21231, USA.

Abstract

It is now well established that cancer is a genetic disease and that somatic mutations of oncogenes and tumour suppressor genes are the initiators of the carcinogenic process. The phosphatidylinositol 3-kinase signalling pathway has previously been implicated in tumorigenesis, and evidence over the past year suggests a pivotal role for the phosphatidylinositol 3-kinase catalytic subunit, PIK3CA, in human cancers. In this review, we analyse recent reports describing PIK3CA mutations in a variety of human malignancies, and discuss their possible implications for diagnosis and therapy.

PMID:
16449998
PMCID:
PMC2361173
DOI:
10.1038/sj.bjc.6602970
[Indexed for MEDLINE]
Free PMC Article

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