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J Clin Invest. 1992 Aug;90(2):626-30.

Widespread long-term gene transfer to mouse skeletal muscles and heart.

Author information

1
Institut Gustave Roussy, Centre National de la Recherche Scientifique, UA 1301, Villejuif, France.

Abstract

Successful treatment of muscular disorders awaits an adapted gene delivery protocol. The clinically applicable technique used for hematopoietic cells which is centered around implantation of retrovirally modified cells may not prove sufficient for a reversal of phenotype when muscle diseases are concerned. We report here efficient, long-term in vivo gene transfer throughout mouse skeletal and cardiac muscles after intravenous administration of a recombinant adenovirus. This simple, direct procedure raises the possibility that muscular degenerative diseases might one day be treatable by gene therapy.

PMID:
1644927
PMCID:
PMC443142
DOI:
10.1172/JCI115902
[Indexed for MEDLINE]
Free PMC Article

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