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Infection. 1992 May-Jun;20(3):168-70.

Comparison of the efficacy of cilofungin, fluconazole and amphotericin B in the treatment of systemic Candida albicans infection in the neutropenic mouse.

Author information

1
Dept. of Microbiology, St. Micheal's Hospital, Toronto, Canada.

Abstract

The relative efficacies of cilofungin, amphotericin B and fluconazole were compared in the treatment of systemic Candida albicans infection in neutropenic mice. Thirty-one day survival rates were lowest for cilofungin (14.6%), intermediate for amphotericin B (37.6%) and highest for fluconazole (50.5%). Residual tissue infection in surviving animals was observed with all agents, but was heaviest with fluconazole, especially in the kidneys.

PMID:
1644494
DOI:
10.1007/bf01704614
[Indexed for MEDLINE]

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