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Nat Immunol. 2006 Mar;7(3):247-55. Epub 2006 Jan 29.

T cells use two directionally distinct pathways for cytokine secretion.

Author information

1
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA.

Abstract

Activated T helper cells produce many cytokines, some of which are secreted through the immunological synapse toward the antigen-presenting cell. Here we have used immunocytochemistry, live-cell imaging and a surface-mediated secretion assay to show that there are two cytokine export pathways in T helper cells. Some cytokines, including interleukin 2 and interferon-gamma, were secreted into the synapse, whereas others, including tumor necrosis factor and the chemokine CCL3 (MIP-1alpha), were released multidirectionally. Each secretion pathway was associated with different trafficking proteins, indicating that they are molecularly distinct processes. These data suggest that T helper cells release some cytokines into the immunological synapse to impart specific communication and others multidirectionally to promote inflammation and to establish chemokine gradients.

PMID:
16444260
DOI:
10.1038/ni1304
[Indexed for MEDLINE]

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