How cyclodextrins can mask their toxic effect on the blood-brain barrier

Cécile Binkowski-Machut; Frédéric Hapiot; Patrick Martin; Roméo Cecchelli; Eric Monflier

doi:10.1016/j.bmcl.2006.01.031

How cyclodextrins can mask their toxic effect on the blood-brain barrier

Bioorg Med Chem Lett. 2006 Apr 1;16(7):1784-7. doi: 10.1016/j.bmcl.2006.01.031. Epub 2006 Jan 25.

Authors

Cécile Binkowski-Machut¹, Frédéric Hapiot, Patrick Martin, Roméo Cecchelli, Eric Monflier

Affiliation

¹ Laboratoire de Physico-Chimie des Interfaces et Applications, FRE CNRS 2485, Faculté des Sciences Jean Perrin, Université d'Artois, rue Jean Souvraz, SP.18-62307 Lens Cédex, France.

PMID: 16442287
DOI: 10.1016/j.bmcl.2006.01.031

Abstract

The toxicity of monosubstituted n-alkyldimethylammonium-beta-cyclodextrins (DMA-C(n)-CD with n=2, 4 and 12) towards endothelial cells of an in vitro model of the blood-brain barrier (BBB) was evaluated and compared to that of the native beta-CD. DMA-C(12)-CD was found to be non-toxic below 10mM due to the self-inclusion of the alkyl chain in the CD cavity. A high percentage of passage (30%) of DMA-C(12)-CD through the endothelial cells has been measured.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Blood-Brain Barrier / drug effects*
Cyclodextrins / toxicity*

Substances

Cyclodextrins