Abstract
Lactate and H(+) are suggested to promote the sickling process in red blood cells (RBCs) containing hemoglobin S. We demonstrated greater activity of the RBC monocarboxylate cotransporter MCT-1, lower RBC deformability and impaired hematological indices in sickle cell trait (SCT) carriers compared to control subjects, suggesting an involvement of MCT-1 in hemorheological disturbances in SCT carriers.
MeSH terms
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Adolescent
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Adult
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Blotting, Western
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Case-Control Studies
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Chromatography, High Pressure Liquid
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Erythrocyte Deformability / physiology*
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Erythrocyte Indices
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Erythrocytes, Abnormal / chemistry*
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Erythrocytes, Abnormal / physiology
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Hemoglobins / analysis
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Hemorheology
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Humans
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Microcirculation / physiopathology
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Monocarboxylic Acid Transporters / analysis*
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Monocarboxylic Acid Transporters / physiology*
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Sickle Cell Trait / blood*
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Sickle Cell Trait / physiopathology
Substances
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Hemoglobins
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Monocarboxylic Acid Transporters