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Fitoterapia. 2006 Feb;77(2):116-20. Epub 2006 Jan 24.

Tannins from barks of Pinus caribaea protect Escherichia coli cells against DNA damage induced by gamma-rays.

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Centro de Aplicaciones Tecnol├│gicas y Desarrollo Nuclear (CEADEN), Miramar, Playa, Ciudad de la Habana, Cuba.


This work was aimed to evaluate genotoxicity and antigenotoxicity activity against gamma-rays of a tannin fraction obtained from barks of Pinus caribaea, as well as to elucidate the antigenotoxic mechanisms involved in radioprotection by using different approaches as pre-, co- and post-irradiation cell treatments with plant extract. The tannin fraction was not genotoxic to Escherichia coli cells in experiments using different exposure times. This extract was antigenotoxic against gamma-rays when the cells were pre- or co-treated with this extracts, but not during post-irradiation treatments, suggesting a possibly antigenotoxic action through free radical scavenging mechanisms. The results are discussed in relation to the chemopreventive and therapeutic potential of the studied plant species.

[Indexed for MEDLINE]

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