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World J Gastroenterol. 2005 Dec 14;11(46):7248-53.

MORT1/FADD is involved in liver regeneration.

Author information

1
Department of Medicine University of Mainz, Langenbeckstr. 1, Mainz 55101, Germany. schuchm@mail.uni-mainz.de

Abstract

AIM:

To explore the role of the adaptor molecule in liver regeneration after partial hepatectomy (PH).

METHODS:

We used transgenic mice expressing an N-terminal truncated form of MORT1/FADD under the control of the albumin promoter. As previously shown, this transgenic protein abrogated CD95- and CD120a-mediated apoptosis in the liver. Cyclin A expression was detected using Western blotting. ELISA and RT-PCR were used to detect IL-6 and IL-6 mRNA, respectively. DNA synthesis in liver tissue was measured by BrdU staining.

RESULTS:

Resection of 70% of the liver was followed by a reduced early regenerative response in the transgenic group at 36 h. Accordingly, 36 h after hepatectomy, cyclin A expression was only detectable in wild-type animals. Consequently, the onset of liver mass restoration was retarded as measured by MRI volumetry and mortality was significantly higher in the transgenic group.

CONCLUSION:

Our data demonstrate for the first time an involvement of the death receptor molecule MORT1/FADD in liver regeneration, beyond its well described role as part of the intracellular death signaling pathway.

PMID:
16437623
PMCID:
PMC4725154
[Indexed for MEDLINE]
Free PMC Article
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