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Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1307-12. Epub 2006 Jan 24.

Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila.

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1
Department of Cell Biology, Harvard Medical School, Massachusetts General Hospital Cancer Center, 13th Street, Charlestown, MA 02129, USA.

Abstract

Deregulation of energy metabolism by external interventions or mutations in metabolic genes can extend lifespan in a wide range of species. We describe mutations in Drosophila melanogaster that confer resistance to oxidative stress and display a longevity phenotype. These phenotypes are associated with molecular lesions in a hitherto uncharacterized gene we named Enigma. We show that Enigma encodes a mitochondrial protein with homology to enzymes of the beta-oxidation of fatty acids and that mutations in this locus affect lipid homeostasis. Our analysis provides further support to the notion that lipid metabolism may play a central role in metazoan lifespan regulation.

PMID:
16434470
PMCID:
PMC1360589
DOI:
10.1073/pnas.0510564103
[Indexed for MEDLINE]
Free PMC Article
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