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Bioinformatics. 2006 May 1;22(9):1088-95. Epub 2006 Jan 24.

Discontinuous epitope prediction based on mimotope analysis.

Author information

1
CNRS UMR 5160, Centre de Pharmacologie et Biotechnologie pour la Santé Faculté de Pharmacie, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France.

Abstract

MOTIVATION:

Phage display is a widespread technique used to obtain peptide mimotopes selected by binding to a given monoclonal antibody in a similar way as the native epitope. However, the localization of the interaction site mimicked by the mimotopes on the surface of the antigen is not always a straightforward task. MIMOP is a computational tool developed with the aim of helping experimentalists to analyze a set of mimotope sequences and guide them in the identification of the mimicked region.

RESULTS:

To predict potential epitopic regions, MIMOP integrates two different approaches combining two- and three-dimensional analyses: MimAlign starts from degenerated alignment analyses, and MimCons is based on consensus identification. The relevance and usefulness of the tool are illustrated by four use cases corresponding to real-life situations.

PMID:
16434442
DOI:
10.1093/bioinformatics/btl012
[Indexed for MEDLINE]

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