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J Exp Med. 2006 Feb 20;203(2):269-73. Epub 2006 Jan 23.

Thymic stromal lymphopoietin: master switch for allergic inflammation.

Author information

1
Department of Immunology and Center of Cancer Immunology Research, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. yjliu@mdanderson.org

Abstract

Thymic stromal lymphopoietin (TSLP) is an interleukin (IL) 7-like cytokine that triggers dendritic cell-mediated T helper (Th)2 inflammatory responses. TSLP is highly expressed by keratinocytes in skin lesions of patients with atopic dermatitis and is associated with dendritic cell activation in situ, suggesting that TSLP might be a master switch for allergic inflammation at the epithelial cell-dendritic cell interface. New reports now establish a direct link between TSLP expression and the pathogenesis of atopic dermatitis and asthma in vivo, and begin to reveal the molecular mechanisms underlying TSLP-induced allergic inflammation.

PMID:
16432252
PMCID:
PMC2118215
DOI:
10.1084/jem.20051745
[Indexed for MEDLINE]
Free PMC Article
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