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Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1283-8. Epub 2006 Jan 23.

Mitochondrial transfer between cells can rescue aerobic respiration.

Author information

1
Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA.

Abstract

Current theory indicates that mitochondria were obtained 1.5 billion years ago from an ancient prokaryote. The mitochondria provided the capacity for aerobic respiration, the creation of the eukaryotic cell, and eventually complex multicellular organisms. Recent reports have found that mitochondria play essential roles in aging and determining lifespan. A variety of heritable and acquired diseases are linked to mitochondrial dysfunction. We report here that mitochondria are more dynamic than previously considered: mitochondria or mtDNA can move between cells. The active transfer from adult stem cells and somatic cells can rescue aerobic respiration in mammalian cells with nonfunctional mitochondria.

PMID:
16432190
PMCID:
PMC1345715
DOI:
10.1073/pnas.0510511103
[Indexed for MEDLINE]
Free PMC Article

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