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Am J Med. 2006 Jan;119(1):50-3.

Family history for venous thromboembolism and the risk for recurrence.

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  • 1Department of Internal Medicine I, Division of Angiology, Medical University of Vienna, Vienna, Austria.

Abstract

PURPOSE:

The relevance of a family history for venous thromboembolism with regard to the likelihood for recurrence is unknown.

SUBJECTS AND METHODS:

We studied 826 patients for an average of 36 months after a first unprovoked venous thromboembolism and withdrawal of oral anticoagulation. Patients with cancer, lupus anticoagulant, or deficiency of antithrombin, protein C, or protein S were excluded. The study endpoint was objective evidence of recurrent symptomatic venous thromboembolism.

RESULTS:

Recurrence for venous thromboembolism was recorded in 23 of 190 patients (12.1%) with a family history (at least one affected first-degree family member) and in 79 of 636 patients (12.4%) without familial thrombosis (relative risk for recurrence 1.0; 95% confidence interval, 0.7-1.6; P=.9). At 5 years, the likelihood for recurrence was 20% among patients with a family history for venous thromboembolism and 18% among those without a family history for venous thromboembolism (P=.9). Risk determinants for venous thromboembolism including factor V Leiden, factor II G20210A, and high factor VIII were not statistically different between the 2 groups.

CONCLUSION:

A family history for venous thromboembolism does not segregate patients into high- or low-risk categories and is not suitable to identify patients at increased risk for recurrent venous thromboembolism.

PMID:
16431184
DOI:
10.1016/j.amjmed.2005.04.043
[PubMed - indexed for MEDLINE]
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