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Nat Neurosci. 2006 Feb;9(2):170-2. Epub 2006 Jan 22.

Experience-dependent modification of mechanisms of long-term depression.

Author information

1
Biomedical Science, School of Medicine and Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.

Abstract

Mechanisms of long-term potentiation and depression (LTP and LTD) change considerably during development, but the importance of these changes and the factors that control them is not clear. We found that visual experience triggered a switch in mechanisms of LTD in rat perirhinal cortex, an area critical for visual recognition memory. Thus, changes in synaptic plasticity mechanisms were correlated with the changing physiological demands on the CNS.

PMID:
16429132
DOI:
10.1038/nn1637
[Indexed for MEDLINE]

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