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Nat Rev Neurosci. 2006 Feb;7(2):115-25.

The molecular basis for calcium-dependent axon pathfinding.

Author information

1
Department of Anatomy, University of Wisconsin School of Medicine, Madison, Wisconsin 53706, USA. tmgomez@wisc.edu

Abstract

Ca(2+) signals have profound and varied effects on growth cone motility and guidance. Modulation of Ca(2+) influx and release from stores by guidance cues shapes Ca(2+) signals, which determine the activation of downstream targets. Although the precise molecular mechanisms that underlie distinct Ca(2+)-mediated effects on growth cone behaviours remain unclear, recent studies have identified important players in both the regulation and targets of Ca(2+) signals in growth cones.

PMID:
16429121
DOI:
10.1038/nrn1844
[Indexed for MEDLINE]

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