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J Bacteriol. 2006 Feb;188(3):1188-90.

Topologically fixed SecG is fully functional.

Author information

1
Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute and Materials Science Center Plus, Kerklaan 30, University of Groningen, 9751 NN Haren, The Netherlands.

Abstract

It has been proposed that the bitopic membrane protein SecG undergoes topology inversion during translocation of (pre)proteins via SecYEG. Here we show that SecG covalently cross-linked to SecY cannot invert its topology while remaining fully functional in protein translocation. Our results strongly disfavor topology inversion of SecG during protein translocation.

PMID:
16428426
PMCID:
PMC1347354
DOI:
10.1128/JB.188.3.1188-1190.2006
[Indexed for MEDLINE]
Free PMC Article
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