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J Bacteriol. 2006 Feb;188(3):1175-9.

Salmonella enterica strains lacking the frataxin homolog CyaY show defects in Fe-S cluster metabolism in vivo.

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1
Department of Bacteriology, University of Wisconsin-Madison, 420 Henry Mall, Madison, WI 53706-1502, USA.

Abstract

In Salmonella enterica, the isc operon contains genes necessary for the synthesis of Fe-S clusters and strains lacking this operon have severe defects in a variety of cellular processes. Other cellular loci that impact Fe-S cluster synthesis to a lesser extent have been described. The cyaY locus encodes a frataxin homolog, and it is shown here that lesions in this locus affect Fe-S cluster metabolism. When present in combination with other lesions, mutations in cyaY can result in a strain with more severe defects than those lacking the isc locus.

PMID:
16428423
PMCID:
PMC1347345
DOI:
10.1128/JB.188.3.1175-1179.2006
[Indexed for MEDLINE]
Free PMC Article
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