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J Dermatolog Treat. 2005;16(5-6):327-30.

Combination of oral terbinafine and topical ciclopirox compared to oral terbinafine for the treatment of onychomycosis.

Author information

1
Department of Dermatology, C. Sheba Medical Center, Tel Hashomer, and the Sackler School of Medicine, Tel Aviv University, Israel. felix@post.tau.ac.il

Abstract

BACKGROUND:

Treatment of onychomycosis has recently been enhanced by the introduction of combination therapies.

OBJECTIVE:

To evaluate the efficacy of a combination therapy of ciclopirox nail lacquer and oral terbinafine compared to oral terbinafine monotherapy for the treatment of onychomycosis caused by dermatophytes.

PATIENTS AND METHODS:

Eighty patients with onychomycosis were randomly assigned to receive either oral terbinafine 250 mg/day for 16 weeks or a combination of oral terbinafine 250 mg/day for 16 weeks and topical ciclopirox nail lacquer once daily for 9 months. Both groups were followed up for 9 months from start of treatment.

RESULTS:

After 9 months of treatment, the mycological cure rates were 22/34 (64.7%) for the terbinafine-only group and 30/34 (88.2%) for the combination therapy group (p<0.05). No significant difference was noted in the complete cure rate.

CONCLUSION:

Combination therapy of oral terbinafine and ciclopirox nail lacquer is a safe and more effective treatment for onychomycosis than terbinafine alone, especially in younger patients and in shorter-duration onychomycosis.

PMID:
16428154
DOI:
10.1080/09546630500420183
[Indexed for MEDLINE]

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