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Immunol Today. 1992 May;13(5):179-84.

Intracellular transport of MHC class II molecules.

Author information

1
The Netherlands Cancer Institute, Amsterdam.

Abstract

MHC class II molecules associate, during biosynthesis, with peptides derived from endocytosed antigen. Here, Jacques Neefjes and Hidde Ploegh describe the intracellular transport of MHC class II molecules and its relationship to the binding of peptides in endosomal compartments. They discuss alternative routes for the delivery of antigen to sites at which peptides associate with MHC class II molecules and raise the possibility of cell type-specific differences in the handling of MHC class II molecules, and hence in antigen presentation.

PMID:
1642756
DOI:
10.1016/0167-5699(92)90123-O
[Indexed for MEDLINE]

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