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Immunol Today. 1992 May;13(5):164-8.

Intermolecular cooperativity: a clue to why mice have IgG3?

Author information

1
Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106.

Erratum in

  • Immunol Today 1992 Jul;13(7):247.

Abstract

Mouse IgG3 subclass antibodies predominate in humoral responses to bacterial polysaccharide antigens. The reasons for this isotype restriction are not fully understood. Here, Neil Greenspan and Laurence Cooper propose that intermolecular cooperativity, a novel mechanism of antibody binding, may help to explain the preferential expression of IgG3 antibodies in these responses.

PMID:
1642754
DOI:
10.1016/0167-5699(92)90120-V
[Indexed for MEDLINE]

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