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Brain Res. 2007 Apr 6;1140:19-25. Epub 2006 Jan 19.

ROR alpha in genetic control of cerebellum development: 50 staggering years.

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Biomedical Sciences Graduate Program, UCSD School of Medicine, La Jolla, CA 92093-0644, USA.


The staggerer mutation was first identified at the Jackson Laboratory in 1955. In the ensuing half-century, studies of staggerer mice have provided new insights into developmental neurobiology, gene regulatory networks, and circadian behavior. Recent work has expanded the role of RORalpha, the transcription factor mutated in staggerer, to peripheral tissues, including cholesterol and lipid metabolism, immune function, and bone development. This review focuses on the role of RORalpha in neural development and behavior revealed by the staggerer mutation and subsequent molecular studies.

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