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Clin Chim Acta. 2006 May;367(1-2):181-4. Epub 2006 Jan 19.

Serum IgG4 concentrations in pancreatic and biliary diseases.

Author information

1
Department of Gastroenterology, University of Tokyo, and Department of Gastroenterology, Mitsui Memorial Hospital, Tokyo, Japan. khirano-mitsui@mitsuihosp.or.jp

Abstract

BACKGROUND:

Recently, it has been reported that the serum concentration of IgG4, a minor component of IgG subclasses, is increased in autoimmune pancreatitis. However, data regarding IgG4 concentrations in other pancreatic or biliary diseases have been insufficient.

METHODS:

Serum IgG4 was measured in 116 patients with pancreatic or biliary diseases (35 autoimmune pancreatitis, 24 chronic pancreatitis except autoimmune pancreatitis, 11 primary sclerosing cholangitis, 23 pancreatic cancer, 3 islet cell tumor, 2 papilla cancer, 15 bile duct cancer, and 3 gallbladder cancer patients). The cut-off concentration of IgG4 was 135 mg/dl.

RESULTS:

Increased serum IgG4 was observed in 33 of 35 patients with autoimmune pancreatitis, 0 of 24 with chronic pancreatitis, 4 of 11 with primary sclerosing cholangitis, 0 of 23 with pancreatic cancer, 0 of 3 with islet cell tumor, 0 of 2 with duodenal papilla cancer, 0 of 15 with bile duct cancer and 0 of 3 with gallbladder cancer patients.

CONCLUSIONS:

Serum IgG4 was increased in autoimmune pancreatitis and was within normal limits for other pancreatic or biliary diseases except primary sclerosing cholangitis.

PMID:
16426597
DOI:
10.1016/j.cca.2005.11.031
[Indexed for MEDLINE]
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