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J Sex Med. 2005 May;2(3):428-31.

Use of a visual analog scale to assess pain of injection with intracavernous injection therapy.

Author information

Glickman Urological Institute, Department of Biostatistics and Epidemiology, The Cleveland Clinic, Cleveland, OH 44195, USA.

Erratum in

  • J Sex Med. 2005 Jul;2(4):589. Lane, Brian Z [corrected to Lane, Brian R].



Fear of pain with intracavernosal injection (ICI) therapy may discourage its use in patients with erectile dysfunction (ED).


We prospectively analyzed patient self-report of discomfort with ICI therapy for ED utilizing a visual analog scale from 0 to 10.


Patient self-report using a visual analog scale revealed minimal discomfort, with 59 consecutive patients reporting an average pain score of 1.93 +/- 1.76. There was no statistical difference between self-administered or nurse-administered injections. The volume of the injection also had no statistical effect on pain score, and there was no difference observed between those who received alprostadil alone or combination treatment. Patients with diabetes mellitus did have significantly higher pain scores than other patients (3.31 +/- 2.25 vs. 1.62 +/- 1.39, P = 0.009), even when controlling for other factors.


Clinicians should be aware of the greater potential for discomfort in ED patients with diabetes. In the majority of ED patients, however, discomfort is minimal, and this information should be helpful in alleviating fear of injection in those who may benefit from this therapy.

[Indexed for MEDLINE]

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