Format

Send to

Choose Destination
Br J Cancer. 2006 Feb 13;94(3):341-5.

The telomeric PARP, tankyrases, as targets for cancer therapy.

Author information

1
Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-10-6 Ariake, Koto-ku, Tokyo 135-8550, Japan. hseimiya@jfcr.or.jp

Abstract

The requirement for the maintenance of telomeres by telomerase by most cancer cells for continued proliferation is a target in anticancer strategies. Tankyrases are poly(ADP-ribose) polymerases that enhance telomerase access to telomeres. Tankyrase 1 modulates telomerase inhibition in human cancer cells and is reviewed in this report as a potential telomere-directed anticancer target.

PMID:
16421589
PMCID:
PMC2361147
DOI:
10.1038/sj.bjc.6602951
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center