Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30.

MAPKAP kinases - MKs - two's company, three's a crowd.

Author information

1
Department of Biochemistry, Medical School Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. gaestel.matthias@mh-hannover.de

Abstract

Downstream of mitogen-activated protein kinases (MAPKs), three structurally related MAPK-activated protein kinases (MAPKAPKs or MKs) - MK2, MK3 and MK5 - signal to diverse cellular targets. Although there is no known common function for all three MKs, these kinases are involved in important processes: MKs regulate gene expression at the transcriptional and post-transcriptional level, control cytoskeletal architecture and cell-cycle progression, and are implicated in inflammation and cancer.

PMID:
16421520
DOI:
10.1038/nrm1834
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center