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Acta Paediatr. 2005 Dec;94(12):1837-40.

Hyperglycaemia and insulinopenia in a neonate with cystic fibrosis.

Author information

1
Neonatal Unit, First Department of Paediatrics, Athens University, "Aghia Sophia" Children's Hospital, Athens, Greece. siahanidou@hotmail.com

Abstract

Abnormal glucose tolerance is a frequent late complication of cystic fibrosis (CF), but the prevalence of CF-related diabetes mellitus (CFRD) in children less than 10 y old is less than 2%. The youngest child with CFRD reported to date was 6 mo of age. Insulinopenia is the primary cause of abnormal glucose tolerance/CFRD, but it is unknown whether it may begin in the neonatal period. We describe a case of a neonate with CF who presented with hyperglycaemia in the diabetic range and marked insulinopenia. Insulinopenia and impaired glucose tolerance were permanent findings at 6 and 15 mo of age.

CONCLUSION:

This case suggests that abnormal glucose tolerance/diabetes may occur much earlier in the course of CF, even during neonatal age. Careful follow-up and further studies in CF infants could reveal that the real incidence of glucose intolerance and diabetes in this age group has been underestimated.

[Indexed for MEDLINE]

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