Format

Send to

Choose Destination
Am J Respir Crit Care Med. 2006 Apr 1;173(7):744-50. Epub 2006 Jan 13.

Brain natriuretic peptide is a prognostic parameter in chronic lung disease.

Author information

1
Division of Pulmonary Diseases, Department of Internal Medicine I, Ludwig Maximilians University, Klinikum Grosshadern, Munich, Germany.

Abstract

RATIONALE:

The detection of pulmonary hypertension in patients with chronic lung disease has prognostic implications. The brain natriuretic peptide (BNP) has been suggested as a noninvasive marker for the presence and severity of pulmonary hypertension.

OBJECTIVES:

We evaluated circulating BNP levels as a parameter for the presence and severity of pulmonary hypertension in patients with chronic lung disease.

METHODS:

BNP levels were measured in 176 consecutive patients with various pulmonary diseases. Right heart catheterization, lung functional testing, and a 6-min walk test were performed. The mean follow-up time was nearly 1 yr.

MEASUREMENTS AND MAIN RESULTS:

Significant pulmonary hypertension (mean pulmonary artery pressure > 35 mm Hg) was diagnosed in more than one-fourth of patients and led to decreased exercise tolerance and life expectancy. Elevated BNP concentrations identified significant pulmonary hypertension with a sensitivity of 0.85 and specificity of 0.88 and predicted mortality. Moreover, BNP served as a risk factor of death independent of lung functional impairment or hypoxemia in uni- and multivariate analysis.

CONCLUSION:

We suggest BNP as a prognostic marker and as screening parameter for significant pulmonary hypertension in chronic lung disease.

PMID:
16415273
DOI:
10.1164/rccm.200510-1545OC
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center